SP01: Mergner

Project Leader: Julia Mergner

Important aspects of cellular programs like cell death are executed through changes in protein abundance levels, post-translational modification (PTM) status or protein-protein interactions, which singly or in combination modulate the molecular network of a cell. Knowledge about this vast functional diversity requires direct measurements at the protein level to generate additional or complementary biological information to measurements available through genomic and transcriptomic technologies. Mass spectrometry-based proteomics has emerged here as a powerful technique to enable unbiased system-wide studies of the global proteome as well as targeted elucidation of specific protein and pathway characteristics. Therefore, this central project aims to support research within numerous subprojects of the TRR 353 by providing the necessary scientific expertise related to state-of-the-art mass spectrometry-based proteomics, together with support for project planning, data generation and interpretation as well as the training of young scientists.